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  • Does a Clinical Decision Rule Using D-Dimer Level Improve the Yield of Pulmonary CT Angiography?

    AJR:196, May 2011

    Guy W. Soo Hoo Carol C. Wu Sondra Vazirani, Zhaoping Li, Bruce M. Barack

    OBJECTIVE. The objective of our study was to evaluate the impact of incorporating a mandatory clinical decision rule and selective D-dimer use on the yield of pulmonary CT an­giography (CTA).

    MATERIALS AND METHODS. Guidelines incorporating a clinical decision rule (Wells score: range, 0-12.5) and a highly sensitive D-dimer assay as decision points were placed into a computerized order entry menu. From December 2006 through November 2008, 261 pulmonary CTA examinations of 238 men and 14 women (mean age ± SD, 65 ± 12 years; range, 31-92 years) were performed. Eight patients underwent more than one pulmonary CTA examination. Charts were reviewed. The results of pulmonary CTA, the clinical deci­sion rule, and D-dimer level (if obtained) were analyzed with the Student t test, chi-square test, or other comparisons using statistical software (MedCalc, version 11.0).

    RESULTS. Of the pulmonary CTA examinations, 16.5% (43/261) were positive for pul­monary embolism (PE) compared with 3.1% (6/196) during the previous 2 years. The mean clinical decision rule score and mean D-dimer level were 5.5 ± 2.4 (SD) and 4956 ± 2892 ng/ mL, respectively, for those with PE compared with 4.5 ±2.1 and 2398 ± 2100 ng/mL for those without PE (both, p < 0.01). The negative predictive value of a clinical decision rule score of 4 or less and D-dimer level of less than 1000 ng/mL was 1.0. A clinical decision rule of greater than 4 and a higher D-dimer level were better predictors for PE, especially a D-dimer level of greater than 3000 ng/mL (odds ratio = 6.69; 95% CI = 2.72-16.43).

    CONCLUSION. Guidelines combining a clinical decision rule with D-dimer level sig­nificantly improved the utilization of pulmonary CTA and positive yield for PE.