AJR:194, March 2010

Mitral Valve Prolapse: Evaluation With ECG-Gated Cardiac CT Angiography

Rajnil G. Shah, Gian M. Novaro, Rodolfo J.BIandon, Lana Wilkinson, Craig R.Asher, Jacobo Kirsch

OBJECTIVE. The purpose of our study was to evaluate the feasibility of detecting mi¬tral valve prolapse with ECG-gated 64-MDCT angiography in comparison with the reference standard, transthoracic echocardiography.

MATERIALS AND METHODS. The charts of patients consecutively referred for clini¬cally indicated 64-MDCT angiography were reviewed. The study cohort consisted of patients who had undergone transthoracic echocardiography. Two experienced radiologists performed blinded consensus review of the MDCT angiograms of 20 patients, and the findings were com¬pared with those of transthoracic echocardiography, which was the reference standard.

RESULTS. With the findings on each anterior and posterior leaflet as separate data points, sensitivity was calculated to be 69.2-84.6% and specificity, 100%. The positive and negative predictive values were estimated to be 100% and 87.0-93.1%.

CONCLUSION. ECG-gated cardiac 64-MDCT angiography can be used reliably to de¬tect mitral valve prolapse.